Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Tlcd5 KO Male
M
12wk
B6N(Cg)-Tmem136<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Tlcd5 KO Female
F
12wk
B6N(Cg)-Tmem136<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Tlcd5 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Tlcd5 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Tlcd5 WT Male (Mean ± SD) | Tlcd5 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 44.43 ± 10.95 | 72.42 ± 4.46 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 17.55 ± 4.87 | 33.10 ± 5.44 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 26.68 ± 5.78 | 38.81 ± 2.85 | 0.0027* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 0.76 ± 0.24 | 5.32 ± 0.62 | <0.001* |
| Body Weight (g) | 25.65 ± 2.24 | 25.23 ± 1.21 | 0.6923 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.297 ± 0.060 | 0.336 ± 0.068 | 0.3620 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 12.62 ± 2.12 | 8.40 ± 0.92 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 39.49 ± 4.60 | 45.79 ± 5.22 | 0.0717 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.60 ± 0.21 | 1.43 ± 0.11 | 0.1521 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 17.54 ± 2.25 | 23.43 ± 3.59 | 0.0098* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 60.51 ± 4.60 | 54.21 ± 5.22 | 0.0717 |
| Trabecular Number (Tb.N) (#/mm) | 2.53 ± 0.35 | 1.99 ± 0.29 | 0.0099* |
| Trabecular Spacing (Tb.Sp) (µm) | 358.45 ± 58.21 | 470.79 ± 68.17 | 0.0069* |
| Trabecular Thickness (Tb.Th) (µm) | 48.07 ± 5.14 | 45.74 ± 3.69 | 0.3712 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 13.54 ± 3.19 | 24.79 ± 3.00 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 3.21 ± 0.64 | 9.26 ± 2.18 | 0.0041* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 9.98 ± 1.80 | 16.00 ± 1.59 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.90 ± 5.52 | 65.11 ± 4.96 | 0.0014* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 24.25 ± 3.87 | 36.40 ± 5.38 | 0.0020* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 75.75 ± 3.87 | 63.60 ± 5.38 | 0.0020* |