Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Acsf2 KO Male
M
12wk
B6N(Cg)-Acsf2<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Acsf2 KO Female
F
12wk
B6N(Cg)-Acsf2<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Acsf2 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Acsf2 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Acsf2 WT Male (Mean ± SD) | Acsf2 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 64.73 ± 8.79 | 68.29 ± 5.68 | 0.3966 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 30.92 ± 4.16 | 41.81 ± 3.40 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 31.80 ± 8.14 | 26.04 ± 2.98 | 0.1422 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 2.57 ± 0.54 | 7.09 ± 1.00 | <0.001* |
| Body Weight (g) | 22.97 ± 0.94 | 20.61 ± 0.79 | <0.001* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.385 ± 0.055 | 0.495 ± 0.049 | 0.0031* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 9.76 ± 1.42 | 11.90 ± 1.38 | 0.0127* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 49.76 ± 7.81 | 61.69 ± 1.68 | 0.0092* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.43 ± 0.20 | 1.48 ± 0.11 | 0.5698 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 24.67 ± 4.28 | 33.60 ± 1.46 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 50.24 ± 7.81 | 38.31 ± 1.68 | 0.0092* |
| Trabecular Number (Tb.N) (#/mm) | 2.04 ± 0.20 | 2.50 ± 0.31 | 0.0054* |
| Trabecular Spacing (Tb.Sp) (µm) | 465.87 ± 55.91 | 360.64 ± 47.28 | 0.0019* |
| Trabecular Thickness (Tb.Th) (µm) | 46.84 ± 3.86 | 46.85 ± 2.03 | 0.9950 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 20.60 ± 2.65 | 24.59 ± 1.23 | 0.0028* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.23 ± 1.76 | 12.79 ± 1.27 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.21 ± 3.15 | 11.26 ± 1.12 | 0.5037 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 80.37 ± 3.44 | 81.40 ± 3.73 | 0.5979 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 41.51 ± 11.26 | 53.16 ± 2.83 | 0.0446* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 58.49 ± 11.26 | 46.84 ± 2.83 | 0.0446* |