Skeletal Phenotyping of Igfl3 Knockout Mice

ROSSA-20260926-6911

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Igfl3 KO Male M 12wk
B6N(Cg)-Igfl3<tm1b(EUCOMM)Hmgu>/J (C57BL/6NTac) • KO/KO
Igfl3 KO Female F 12wk
B6N(Cg)-Igfl3<tm1b(EUCOMM)Hmgu>/J (C57BL/6NTac) • KO/KO
Igfl3 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Igfl3 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Igfl3 WT Male (Mean ± SD) Igfl3 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 25.09 ± 1.37 23.75 ± 1.69 0.1241
Bone Mineral Density (mg/ccm HA) 1,142.86 ± 8.34 1,151.70 ± 7.46 0.0554
Cortical Area (mm^2) 0.751 ± 0.063 0.716 ± 0.085 0.3948
Cortical Area / Total Area (%) 40.70 ± 1.60 40.42 ± 1.68 0.7566
Cortical Mask (dimensionless) 0.753 ± 0.064 0.718 ± 0.085 0.3921
Cortical Porosity (%) 0.268 ± 0.032 0.238 ± 0.040 0.1471
Cortical Thickness (mm) 0.166 ± 0.011 0.163 ± 0.013 0.6194
Endocortical Perimeter (mm) 3.70 ± 0.16 3.63 ± 0.12 0.3465
Length (mm) 14.86 ± 0.24 14.76 ± 0.36 0.5427
Marrow Area (mm^2) 1.093 ± 0.093 1.049 ± 0.070 0.3416
Maximum Distance from Centroid (mm) 1.971 ± 0.090 1.929 ± 0.073 0.3542
Maximum Moment of Inertia (mm^4) 0.254 ± 0.037 0.234 ± 0.043 0.3671
Minimum Distance from Centroid (mm) 1.263 ± 0.069 1.241 ± 0.061 0.5422
Minimum Moment of Inertia (mm^4) 0.125 ± 0.021 0.114 ± 0.022 0.3531
Periosteal Perimeter (mm) 4.79 ± 0.29 4.59 ± 0.33 0.2555
Polar Moment of Inertia (mm^4) 0.379 ± 0.058 0.347 ± 0.065 0.3573
Pore Area (mm^2) 0.0020 ± 0.0004 0.0017 ± 0.0004 0.1232
Section Modulus about Maximum Moment of Inertia (mm^3) 0.257 ± 0.027 0.241 ± 0.039 0.4019
Section Modulus about Minimum Moment of Inertia (mm^3) 0.196 ± 0.023 0.182 ± 0.027 0.2985
Tissue Mineral Density (mg/ccm HA) 1,202.92 ± 8.43 1,217.24 ± 4.68 0.0015*
Total Area (mm^2) 1.85 ± 0.15 1.77 ± 0.15 0.3332