Study Datasets
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Akr1b8 KO Male
M
12wk
B6N(Cg)-Akr1b8<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Akr1b8 KO Female
F
12wk
B6N(Cg)-Akr1b8<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Akr1b8 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Akr1b8 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical
| Variable | Akr1b8 WT Male (Mean ± SD) | Akr1b8 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Body Weight (g) | 26.74 ± 1.76 | 22.72 ± 2.31 | 0.0036* |
| Bone Mineral Density (mg/ccm HA) | 1,156.75 ± 10.53 | 1,152.58 ± 14.54 | 0.5489 |
| Cortical Area (mm^2) | 0.792 ± 0.084 | 0.648 ± 0.093 | 0.0088* |
| Cortical Area / Total Area (%) | 41.31 ± 2.11 | 42.21 ± 3.02 | 0.5302 |
| Cortical Mask (dimensionless) | 0.794 ± 0.084 | 0.650 ± 0.093 | 0.0085* |
| Cortical Porosity (%) | 0.34 ± 0.13 | 0.287 ± 0.048 | 0.3065 |
| Cortical Thickness (mm) | 0.174 ± 0.014 | 0.160 ± 0.018 | 0.1191 |
| Endocortical Perimeter (mm) | 3.75 ± 0.21 | 3.32 ± 0.15 | <0.001* |
| Length (mm) | 15.01 ± 0.28 | 14.26 ± 0.54 | 0.0053* |
| Marrow Area (mm^2) | 1.12 ± 0.13 | 0.881 ± 0.077 | <0.001* |
| Maximum Distance from Centroid (mm) | 2.00 ± 0.10 | 1.75 ± 0.13 | 0.0014* |
| Maximum Moment of Inertia (mm^4) | 0.271 ± 0.053 | 0.178 ± 0.044 | 0.0031* |
| Minimum Distance from Centroid (mm) | 1.322 ± 0.087 | 1.194 ± 0.045 | 0.0040* |
| Minimum Moment of Inertia (mm^4) | 0.141 ± 0.033 | 0.091 ± 0.017 | 0.0029* |
| Periosteal Perimeter (mm) | 4.97 ± 0.34 | 4.08 ± 0.40 | <0.001* |
| Polar Moment of Inertia (mm^4) | 0.412 ± 0.086 | 0.269 ± 0.061 | 0.0028* |
| Pore Area (mm^2) | 0.0027 ± 0.0009 | 0.0019 ± 0.0004 | 0.0392* |
| Section Modulus about Maximum Moment of Inertia (mm^3) | 0.269 ± 0.038 | 0.201 ± 0.036 | 0.0042* |
| Section Modulus about Minimum Moment of Inertia (mm^3) | 0.211 ± 0.033 | 0.152 ± 0.026 | 0.0023* |
| Tissue Mineral Density (mg/ccm HA) | 1,219.11 ± 8.48 | 1,221.31 ± 11.44 | 0.6888 |
| Total Area (mm^2) | 1.92 ± 0.20 | 1.53 ± 0.15 | 0.0010* |