Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Vcpkmt KO Male
M
12wk
B6N(Cg)-Vcpkmt<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Vcpkmt KO Female
F
12wk
B6N(Cg)-Vcpkmt<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Vcpkmt WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Vcpkmt WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Vcpkmt WT Male (Mean ± SD) | Vcpkmt KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 62.08 ± 9.91 | 42.52 ± 4.55 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 36.04 ± 6.35 | 26.74 ± 4.77 | 0.0258* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 26.70 ± 4.81 | 16.42 ± 2.39 | 0.0016* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 5.98 ± 1.40 | 1.09 ± 0.42 | <0.001* |
| Body Weight (g) | 23.95 ± 0.99 | 21.65 ± 2.24 | 0.0298* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.470 ± 0.082 | 0.496 ± 0.052 | 0.5471 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 9.57 ± 1.67 | 9.79 ± 1.50 | 0.8110 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 57.43 ± 3.93 | 61.66 ± 5.49 | 0.1918 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.462 ± 0.064 | 1.547 ± 0.068 | 0.0471* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 29.95 ± 3.40 | 31.01 ± 2.73 | 0.5831 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 42.57 ± 3.93 | 38.34 ± 5.49 | 0.1918 |
| Trabecular Number (Tb.N) (#/mm) | 2.25 ± 0.32 | 2.14 ± 0.30 | 0.5254 |
| Trabecular Spacing (Tb.Sp) (µm) | 411.85 ± 68.61 | 437.22 ± 75.67 | 0.5542 |
| Trabecular Thickness (Tb.Th) (µm) | 45.17 ± 4.10 | 47.74 ± 4.24 | 0.2862 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 27.25 ± 4.79 | 7.65 ± 1.93 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 12.36 ± 2.03 | 3.56 ± 0.87 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 15.03 ± 3.62 | 3.67 ± 1.52 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.60 ± 4.78 | 80.96 ± 5.88 | 0.1821 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 45.54 ± 4.67 | 50.64 ± 6.27 | 0.1756 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 54.46 ± 4.67 | 49.36 ± 6.27 | 0.1756 |