Skeletal Phenotyping of Dntt Knockout Mice

ROSSA-20260926-5AF7

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Dntt KO Male M 12wk
B6N(Cg)-Dntt<tm2b(KOMP)Wtsi>/2J (C57BL/6NTac) • KO/KO
Dntt KO Female F 12wk
B6N(Cg)-Dntt<tm2b(KOMP)Wtsi>/2J (C57BL/6NTac) • KO/KO
Dntt WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Dntt WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Dntt WT Male (Mean ± SD) Dntt KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 28.21 ± 2.11 27.25 ± 2.10 0.4269
Bone Mineral Density (mg/ccm HA) 1,135.37 ± 9.56 1,144.59 ± 9.86 0.0975
Cortical Area (mm^2) 0.685 ± 0.059 0.769 ± 0.091 0.0585
Cortical Area / Total Area (%) 38.71 ± 1.21 40.26 ± 0.99 0.0202*
Cortical Mask (dimensionless) 0.687 ± 0.059 0.772 ± 0.091 0.0577
Cortical Porosity (%) 0.249 ± 0.026 0.281 ± 0.047 0.1378
Cortical Thickness (mm) 0.154 ± 0.011 0.166 ± 0.013 0.0708
Endocortical Perimeter (mm) 3.69 ± 0.14 3.78 ± 0.21 0.3461
Length (mm) 14.74 ± 0.22 14.96 ± 0.38 0.2065
Marrow Area (mm^2) 1.083 ± 0.081 1.14 ± 0.13 0.3390
Maximum Distance from Centroid (mm) 1.912 ± 0.090 2.00 ± 0.12 0.1239
Maximum Moment of Inertia (mm^4) 0.225 ± 0.038 0.271 ± 0.056 0.0971
Minimum Distance from Centroid (mm) 1.244 ± 0.046 1.283 ± 0.086 0.3146
Minimum Moment of Inertia (mm^4) 0.112 ± 0.016 0.134 ± 0.033 0.1309
Periosteal Perimeter (mm) 4.67 ± 0.29 4.90 ± 0.40 0.2520
Polar Moment of Inertia (mm^4) 0.337 ± 0.054 0.405 ± 0.088 0.1051
Pore Area (mm^2) 0.0017 ± 0.0002 0.0022 ± 0.0003 0.0099*
Section Modulus about Maximum Moment of Inertia (mm^3) 0.234 ± 0.029 0.268 ± 0.040 0.0921
Section Modulus about Minimum Moment of Inertia (mm^3) 0.179 ± 0.020 0.206 ± 0.037 0.1038
Tissue Mineral Density (mg/ccm HA) 1,198.35 ± 9.97 1,206.74 ± 8.53 0.1130
Total Area (mm^2) 1.77 ± 0.13 1.91 ± 0.21 0.1601