Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Try4 KO Male
M
12wk
B6N(Cg)-Try4<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Try4 KO Female
F
12wk
B6N(Cg)-Try4<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Try4 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Try4 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Try4 WT Male (Mean ± SD) | Try4 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 55.31 ± 8.10 | 21.33 ± 12.66 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.62 ± 3.72 | 8.64 ± 4.50 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 25.28 ± 7.84 | 7.38 ± 5.28 | 0.0011* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 5.02 ± 1.08 | 0.65 ± 0.38 | <0.001* |
| Body Weight (g) | 25.33 ± 1.81 | 24.84 ± 1.73 | 0.6122 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.415 ± 0.049 | 0.344 ± 0.039 | 0.0126* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 11.88 ± 1.17 | 12.93 ± 2.20 | 0.2948 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 54.91 ± 8.95 | 56.08 ± 4.83 | 0.7973 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.45 ± 0.13 | 1.45 ± 0.13 | 0.9902 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.46 ± 3.84 | 23.31 ± 2.19 | 0.0099* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 45.09 ± 8.95 | 43.92 ± 4.83 | 0.7973 |
| Trabecular Number (Tb.N) (#/mm) | 2.40 ± 0.24 | 2.53 ± 0.26 | 0.3709 |
| Trabecular Spacing (Tb.Sp) (µm) | 375.20 ± 45.30 | 352.31 ± 47.40 | 0.3900 |
| Trabecular Thickness (Tb.Th) (µm) | 49.36 ± 4.29 | 53.12 ± 4.61 | 0.1361 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 23.11 ± 3.69 | 9.15 ± 1.89 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 11.39 ± 1.02 | 3.40 ± 1.13 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.72 ± 2.62 | 5.44 ± 1.44 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 78.25 ± 4.41 | 80.34 ± 4.08 | 0.3920 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 47.73 ± 6.00 | 37.63 ± 3.80 | 0.0045* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 52.27 ± 6.00 | 62.37 ± 3.80 | 0.0045* |