Skeletal Phenotyping of Spata7 Knockout Mice

ROSSA-20260926-55A8

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Spata7 KO Male M 12wk
B6N(Cg)-Spata7<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Spata7 KO Female F 12wk
B6N(Cg)-Spata7<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Spata7 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Spata7 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Spata7 WT Male (Mean ± SD) Spata7 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 25.09 ± 1.37 24.27 ± 1.33 0.2753
Bone Mineral Density (mg/ccm HA) 1,142.86 ± 8.34 1,151.89 ± 9.15 0.0742
Cortical Area (mm^2) 0.751 ± 0.063 0.652 ± 0.042 0.0038*
Cortical Area / Total Area (%) 40.70 ± 1.60 39.14 ± 1.85 0.1137
Cortical Mask (dimensionless) 0.753 ± 0.064 0.653 ± 0.042 0.0038*
Cortical Porosity (%) 0.268 ± 0.032 0.262 ± 0.051 0.8050
Cortical Thickness (mm) 0.166 ± 0.011 0.1509 ± 0.0084 0.0120*
Endocortical Perimeter (mm) 3.70 ± 0.16 3.563 ± 0.075 0.0517
Length (mm) 14.86 ± 0.24 14.70 ± 0.18 0.1787
Marrow Area (mm^2) 1.093 ± 0.093 1.011 ± 0.042 0.0523
Maximum Distance from Centroid (mm) 1.971 ± 0.090 1.868 ± 0.070 0.0303*
Maximum Moment of Inertia (mm^4) 0.254 ± 0.037 0.198 ± 0.020 0.0035*
Minimum Distance from Centroid (mm) 1.263 ± 0.069 1.206 ± 0.027 0.0641
Minimum Moment of Inertia (mm^4) 0.125 ± 0.021 0.0994 ± 0.0081 0.0110*
Periosteal Perimeter (mm) 4.79 ± 0.29 4.48 ± 0.12 0.0229*
Polar Moment of Inertia (mm^4) 0.379 ± 0.058 0.298 ± 0.027 0.0046*
Pore Area (mm^2) 0.0020 ± 0.0004 0.0017 ± 0.0004 0.1479
Section Modulus about Maximum Moment of Inertia (mm^3) 0.257 ± 0.027 0.212 ± 0.014 0.0016*
Section Modulus about Minimum Moment of Inertia (mm^3) 0.196 ± 0.023 0.165 ± 0.011 0.0057*
Tissue Mineral Density (mg/ccm HA) 1,202.92 ± 8.43 1,222.60 ± 7.84 <0.001*
Total Area (mm^2) 1.85 ± 0.15 1.664 ± 0.060 0.0086*