Skeletal Phenotyping of Serpinb5 Knockout Mice

ROSSA-20260926-5590

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Serpinb5 KO Male M 12wk
B6N(Cg)-Serpinb5<tm1b(KOMP)Wtsi>/J (C57BL/6NTac) • KO/KO
Serpinb5 KO Female F 12wk
B6N(Cg)-Serpinb5<tm1b(KOMP)Wtsi>/J (C57BL/6NTac) • KO/KO
Serpinb5 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Serpinb5 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Serpinb5 WT Male (Mean ± SD) Serpinb5 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 24.87 ± 2.15 24.18 ± 0.61 0.4395
Bone Mineral Density (mg/ccm HA) 1,150.63 ± 12.21 1,151.88 ± 4.34 0.8019
Cortical Area (mm^2) 0.760 ± 0.090 0.755 ± 0.039 0.8979
Cortical Area / Total Area (%) 40.37 ± 1.94 39.62 ± 0.74 0.3631
Cortical Mask (dimensionless) 0.762 ± 0.091 0.758 ± 0.041 0.9083
Cortical Porosity (%) 0.284 ± 0.040 0.34 ± 0.17 0.4198
Cortical Thickness (mm) 0.168 ± 0.011 0.1652 ± 0.0052 0.6310
Endocortical Perimeter (mm) 3.75 ± 0.31 3.797 ± 0.099 0.7227
Length (mm) 14.91 ± 0.33 14.65 ± 0.21 0.1014
Marrow Area (mm^2) 1.13 ± 0.19 1.148 ± 0.061 0.7929
Maximum Distance from Centroid (mm) 1.96 ± 0.17 2.042 ± 0.058 0.2522
Maximum Moment of Inertia (mm^4) 0.258 ± 0.070 0.268 ± 0.026 0.7205
Minimum Distance from Centroid (mm) 1.32 ± 0.10 1.288 ± 0.042 0.5014
Minimum Moment of Inertia (mm^4) 0.137 ± 0.037 0.128 ± 0.015 0.6025
Periosteal Perimeter (mm) 4.90 ± 0.54 4.80 ± 0.21 0.6628
Polar Moment of Inertia (mm^4) 0.39 ± 0.11 0.396 ± 0.040 0.9592
Pore Area (mm^2) 0.0022 ± 0.0004 0.0026 ± 0.0015 0.4561
Section Modulus about Maximum Moment of Inertia (mm^3) 0.259 ± 0.048 0.262 ± 0.018 0.8980
Section Modulus about Minimum Moment of Inertia (mm^3) 0.204 ± 0.040 0.199 ± 0.018 0.7582
Tissue Mineral Density (mg/ccm HA) 1,214.53 ± 10.99 1,217.65 ± 5.62 0.5142
Total Area (mm^2) 1.89 ± 0.27 1.905 ± 0.096 0.8870