Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Dixdc1 KO Male
M
12wk
B6N(Cg)-Dixdc1 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Dixdc1 KO Female
F
12wk
B6N(Cg)-Dixdc1 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Dixdc1 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Dixdc1 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Dixdc1 WT Male (Mean ± SD) | Dixdc1 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 57.17 ± 6.50 | 78.99 ± 3.49 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 21.17 ± 2.38 | 36.19 ± 3.90 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 36.42 ± 5.86 | 43.06 ± 4.60 | 0.0495* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 1.47 ± 0.38 | 2.95 ± 0.80 | 0.0015* |
| Body Weight (g) | 27.39 ± 1.23 | 27.77 ± 1.32 | 0.5879 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.227 ± 0.024 | 0.477 ± 0.062 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.91 ± 2.03 | 17.57 ± 3.05 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 36.93 ± 3.03 | 45.67 ± 4.96 | 0.0031* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.37 ± 0.10 | 2.07 ± 0.21 | <0.001* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 16.46 ± 1.50 | 24.50 ± 3.22 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 63.07 ± 3.03 | 54.33 ± 4.96 | 0.0031* |
| Trabecular Number (Tb.N) (#/mm) | 2.58 ± 0.23 | 4.28 ± 0.51 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 353.44 ± 37.74 | 203.78 ± 37.48 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 42.27 ± 6.22 | 42.15 ± 6.22 | 0.9725 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 26.12 ± 2.21 | 20.39 ± 3.49 | 0.0025* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 6.33 ± 1.11 | 6.72 ± 1.48 | 0.6165 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 22.00 ± 3.51 | 14.03 ± 2.86 | 0.0010* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 68.17 ± 5.31 | 86.17 ± 2.80 | <0.001* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 22.46 ± 2.99 | 32.57 ± 5.64 | 0.0022* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 77.54 ± 2.99 | 67.43 ± 5.64 | 0.0022* |