Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Adck2 KO Male
M
12wk
B6N(Cg)-Adck2<1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Adck2 KO Female
F
12wk
B6N(Cg)-Adck2<1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Adck2 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Adck2 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Adck2 WT Male (Mean ± SD) | Adck2 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 61.20 ± 13.24 | 23.68 ± 13.58 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 35.08 ± 7.04 | 17.73 ± 8.19 | 0.0049* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 25.85 ± 7.79 | 9.89 ± 5.39 | 0.0037* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.72 ± 1.32 | 1.56 ± 0.88 | 0.0123* |
| Body Weight (g) | 21.69 ± 1.54 | 19.90 ± 1.03 | 0.0233* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.402 ± 0.033 | 0.564 ± 0.084 | 0.0111* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 11.91 ± 1.25 | 12.08 ± 2.00 | 0.8562 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 58.22 ± 4.40 | 65.81 ± 5.36 | 0.0344* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.47 ± 0.13 | 1.81 ± 0.27 | 0.0127* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 29.38 ± 1.78 | 31.30 ± 1.84 | 0.1242 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 41.78 ± 4.40 | 34.19 ± 5.36 | 0.0344* |
| Trabecular Number (Tb.N) (#/mm) | 2.26 ± 0.27 | 2.29 ± 0.30 | 0.8615 |
| Trabecular Spacing (Tb.Sp) (µm) | 396.34 ± 52.89 | 395.52 ± 59.91 | 0.9787 |
| Trabecular Thickness (Tb.Th) (µm) | 53.97 ± 5.48 | 53.32 ± 3.49 | 0.7957 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 14.43 ± 3.75 | 10.76 ± 2.40 | 0.0462* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 6.85 ± 2.10 | 6.16 ± 1.54 | 0.5705 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 7.35 ± 2.71 | 4.94 ± 1.46 | 0.1104 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.63 ± 5.29 | 91.05 ± 3.26 | 0.0809 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 48.67 ± 6.44 | 55.63 ± 6.16 | 0.1115 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.33 ± 6.44 | 44.37 ± 6.16 | 0.1115 |