Skeletal Phenotyping of Rps6kl1 Knockout Mice

ROSSA-20260926-5288

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Rps6kl1 KO Male M 12wk
B6N(Cg)-Rps6kl1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Rps6kl1 KO Female F 12wk
B6N(Cg)-Rps6kl1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Rps6kl1 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Rps6kl1 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Rps6kl1 WT Male (Mean ± SD) Rps6kl1 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 25.32 ± 1.77 25.79 ± 1.11 0.5796
Bone Mineral Density (mg/ccm HA) 1,158.74 ± 9.85 1,156.66 ± 13.94 0.7589
Cortical Area (mm^2) 0.717 ± 0.084 0.728 ± 0.042 0.7686
Cortical Area / Total Area (%) 42.32 ± 1.47 41.34 ± 1.91 0.3164
Cortical Mask (dimensionless) 0.719 ± 0.084 0.730 ± 0.042 0.7738
Cortical Porosity (%) 0.265 ± 0.038 0.229 ± 0.036 0.1047
Cortical Thickness (mm) 0.165 ± 0.013 0.165 ± 0.011 0.9732
Endocortical Perimeter (mm) 3.49 ± 0.14 3.599 ± 0.042 0.1051
Length (mm) 14.72 ± 0.22 15.03 ± 0.18 0.0174*
Marrow Area (mm^2) 0.973 ± 0.080 1.031 ± 0.024 0.1092
Maximum Distance from Centroid (mm) 1.89 ± 0.10 1.942 ± 0.057 0.2925
Maximum Moment of Inertia (mm^4) 0.220 ± 0.043 0.232 ± 0.013 0.5000
Minimum Distance from Centroid (mm) 1.218 ± 0.066 1.232 ± 0.029 0.6393
Minimum Moment of Inertia (mm^4) 0.110 ± 0.023 0.1143 ± 0.0082 0.6303
Periosteal Perimeter (mm) 4.51 ± 0.27 4.73 ± 0.10 0.0808
Polar Moment of Inertia (mm^4) 0.329 ± 0.066 0.346 ± 0.020 0.5399
Pore Area (mm^2) 0.0019 ± 0.0003 0.0017 ± 0.0003 0.1930
Section Modulus about Maximum Moment of Inertia (mm^3) 0.231 ± 0.034 0.239 ± 0.015 0.5747
Section Modulus about Minimum Moment of Inertia (mm^3) 0.178 ± 0.027 0.1854 ± 0.0097 0.5526
Tissue Mineral Density (mg/ccm HA) 1,223.43 ± 9.28 1,220.93 ± 12.84 0.6913
Total Area (mm^2) 1.69 ± 0.16 1.761 ± 0.025 0.3064