Skeletal Phenotyping of Rexo4 Knockout Mice

ROSSA-20260926-4EDF

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Rexo4 KO Male M 12wk
B6N(Cg)-Rexo4<tm1b(KOMP)Wtsi>/J (C57BL/6NTac) • KO/KO
Rexo4 KO Female F 12wk
B6N(Cg)-Rexo4<tm1b(KOMP)Wtsi>/J (C57BL/6NTac) • KO/KO
Rexo4 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Rexo4 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Rexo4 WT Male (Mean ± SD) Rexo4 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 24.25 ± 1.08 24.79 ± 0.99 0.3431
Bone Mineral Density (mg/ccm HA) 1,136.68 ± 15.95 1,130.70 ± 4.48 0.3675
Cortical Area (mm^2) 0.682 ± 0.077 0.745 ± 0.054 0.0975
Cortical Area / Total Area (%) 40.48 ± 3.77 37.86 ± 1.81 0.1203
Cortical Mask (dimensionless) 0.684 ± 0.077 0.747 ± 0.054 0.0959
Cortical Porosity (%) 0.289 ± 0.042 0.330 ± 0.040 0.0858
Cortical Thickness (mm) 0.158 ± 0.019 0.1593 ± 0.0084 0.9013
Endocortical Perimeter (mm) 3.54 ± 0.13 3.92 ± 0.19 <0.001*
Length (mm) 12.83 ± 4.85 14.75 ± 0.18 0.3127
Marrow Area (mm^2) 0.999 ± 0.070 1.22 ± 0.12 0.0012*
Maximum Distance from Centroid (mm) 1.874 ± 0.048 2.051 ± 0.070 <0.001*
Maximum Moment of Inertia (mm^4) 0.209 ± 0.025 0.268 ± 0.034 0.0023*
Minimum Distance from Centroid (mm) 1.211 ± 0.039 1.339 ± 0.075 0.0012*
Minimum Moment of Inertia (mm^4) 0.103 ± 0.015 0.137 ± 0.022 0.0050*
Periosteal Perimeter (mm) 4.479 ± 0.089 4.95 ± 0.31 0.0048*
Polar Moment of Inertia (mm^4) 0.312 ± 0.039 0.404 ± 0.055 0.0026*
Pore Area (mm^2) 0.0020 ± 0.0003 0.0025 ± 0.0004 0.0137*
Section Modulus about Maximum Moment of Inertia (mm^3) 0.223 ± 0.026 0.260 ± 0.025 0.0166*
Section Modulus about Minimum Moment of Inertia (mm^3) 0.170 ± 0.019 0.203 ± 0.025 0.0145*
Tissue Mineral Density (mg/ccm HA) 1,201.39 ± 12.34 1,192.89 ± 6.27 0.1341
Total Area (mm^2) 1.683 ± 0.080 1.97 ± 0.16 <0.001*