Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Cd33 KO Male
M
12wk
B6N(Cg)-Cd33<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Cd33 KO Female
F
12wk
B6N(Cg)-Cd33<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Cd33 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Cd33 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Cd33 WT Male (Mean ± SD) | Cd33 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 44.75 ± 7.75 | 44.46 ± 27.68 | 0.9797 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 24.33 ± 3.15 | 26.65 ± 16.08 | 0.7631 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 25.25 ± 3.89 | 21.49 ± 12.17 | 0.5248 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 2.05 ± 1.33 | 4.60 ± 2.00 | 0.0491* |
| Body Weight (g) | 23.58 ± 2.52 | 21.75 ± 2.35 | 0.1811 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.355 ± 0.100 | 0.64 ± 0.12 | 0.0012* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.05 ± 2.91 | 11.71 ± 2.32 | 0.2586 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 49.20 ± 4.06 | 53.88 ± 3.83 | 0.0904 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.65 ± 0.22 | 2.18 ± 0.24 | <0.001* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 21.67 ± 3.85 | 28.66 ± 3.17 | 0.0077* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 50.80 ± 4.06 | 46.12 ± 3.83 | 0.0904 |
| Trabecular Number (Tb.N) (#/mm) | 2.13 ± 0.39 | 3.60 ± 0.60 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 449.34 ± 102.10 | 256.25 ± 47.30 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 45.69 ± 6.15 | 36.31 ± 8.77 | 0.0360* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.43 ± 9.10 | 24.59 ± 4.50 | 0.0394* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 5.35 ± 4.35 | 9.66 ± 2.02 | 0.0653 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.77 ± 5.70 | 14.26 ± 3.18 | 0.0800 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.42 ± 6.50 | 80.89 ± 3.16 | 0.1472 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 32.93 ± 11.47 | 40.42 ± 4.92 | 0.1988 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 67.07 ± 11.47 | 59.58 ± 4.92 | 0.1988 |