Skeletal Phenotyping of Bex6 Knockout Mice

ROSSA-20260926-4748

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Bex6 KO Male M 12wk
B6N(Cg)-Bex6Tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Bex6 KO Female F 12wk
B6N(Cg)-Bex6Tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Bex6 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Bex6 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Bex6 WT Male (Mean ± SD) Bex6 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 25.27 ± 1.24 25.64 ± 1.64 0.6428
Bone Mineral Density (mg/ccm HA) 1,144.06 ± 5.55 1,143.19 ± 8.55 0.8246
Cortical Area (mm^2) 0.666 ± 0.038 0.739 ± 0.052 0.0091*
Cortical Area / Total Area (%) 40.54 ± 0.86 39.83 ± 1.49 0.2948
Cortical Mask (dimensionless) 0.667 ± 0.038 0.742 ± 0.052 0.0088*
Cortical Porosity (%) 0.241 ± 0.031 0.34 ± 0.19 0.1813
Cortical Thickness (mm) 0.1555 ± 0.0065 0.1616 ± 0.0095 0.1854
Endocortical Perimeter (mm) 3.498 ± 0.078 3.74 ± 0.12 <0.001*
Length (mm) 14.60 ± 0.11 14.78 ± 0.20 0.0584
Marrow Area (mm^2) 0.974 ± 0.044 1.114 ± 0.073 <0.001*
Maximum Distance from Centroid (mm) 1.858 ± 0.079 1.996 ± 0.063 0.0028*
Maximum Moment of Inertia (mm^4) 0.203 ± 0.026 0.255 ± 0.031 0.0038*
Minimum Distance from Centroid (mm) 1.189 ± 0.027 1.261 ± 0.054 0.0094*
Minimum Moment of Inertia (mm^4) 0.0973 ± 0.0081 0.123 ± 0.015 0.0024*
Periosteal Perimeter (mm) 4.39 ± 0.13 4.78 ± 0.21 0.0011*
Polar Moment of Inertia (mm^4) 0.300 ± 0.034 0.378 ± 0.045 0.0025*
Pore Area (mm^2) 0.0016 ± 0.0002 0.0026 ± 0.0015 0.1143
Section Modulus about Maximum Moment of Inertia (mm^3) 0.218 ± 0.019 0.255 ± 0.024 0.0063*
Section Modulus about Minimum Moment of Inertia (mm^3) 0.164 ± 0.011 0.194 ± 0.017 0.0013*
Tissue Mineral Density (mg/ccm HA) 1,208.77 ± 4.85 1,206.47 ± 8.11 0.5308
Total Area (mm^2) 1.642 ± 0.077 1.86 ± 0.11 <0.001*