Skeletal Phenotyping of Rilpl2 Knockout Mice

ROSSA-20260926-4594

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Rilpl2 KO Male M 12wk
B6N(Cg)-Rilpl2 tm1b(KOMP)Wtsi/J (C57BL/6NTac) • KO/KO
Rilpl2 KO Female F 12wk
B6N(Cg)-Rilpl2 tm1b(KOMP)Wtsi/J (C57BL/6NTac) • KO/KO
Rilpl2 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Rilpl2 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Rilpl2 WT Male (Mean ± SD) Rilpl2 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 22.00 ± 3.26 23.20 ± 1.75 0.4025
Bone Mineral Density (mg/ccm HA) 1,179.19 ± 5.92 1,167.45 ± 6.73 0.0038*
Cortical Area (mm^2) 0.728 ± 0.082 0.712 ± 0.060 0.6738
Cortical Area / Total Area (%) 41.23 ± 1.09 40.11 ± 1.12 0.0778
Cortical Mask (dimensionless) 0.730 ± 0.082 0.714 ± 0.061 0.6743
Cortical Porosity (%) 0.279 ± 0.043 0.27 ± 0.11 0.9171
Cortical Thickness (mm) 0.165 ± 0.010 0.1596 ± 0.0087 0.3011
Endocortical Perimeter (mm) 3.60 ± 0.21 3.65 ± 0.14 0.6589
Length (mm) 14.67 ± 0.36 14.62 ± 0.32 0.7853
Marrow Area (mm^2) 1.04 ± 0.13 1.060 ± 0.081 0.6871
Maximum Distance from Centroid (mm) 1.88 ± 0.15 1.93 ± 0.11 0.5303
Maximum Moment of Inertia (mm^4) 0.227 ± 0.059 0.229 ± 0.040 0.9453
Minimum Distance from Centroid (mm) 1.274 ± 0.062 1.259 ± 0.031 0.5911
Minimum Moment of Inertia (mm^4) 0.121 ± 0.026 0.116 ± 0.015 0.6256
Periosteal Perimeter (mm) 4.60 ± 0.43 4.59 ± 0.29 0.9528
Polar Moment of Inertia (mm^4) 0.349 ± 0.084 0.345 ± 0.054 0.9242
Pore Area (mm^2) 0.0021 ± 0.0005 0.0020 ± 0.0009 0.8537
Section Modulus about Maximum Moment of Inertia (mm^3) 0.238 ± 0.042 0.236 ± 0.030 0.9084
Section Modulus about Minimum Moment of Inertia (mm^3) 0.189 ± 0.031 0.184 ± 0.019 0.6806
Tissue Mineral Density (mg/ccm HA) 1,249.02 ± 9.28 1,236.82 ± 10.12 0.0339*
Total Area (mm^2) 1.77 ± 0.20 1.77 ± 0.14 0.9438