Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Plekha3 KO Male
M
12wk
B6N(Cg)-Plekha3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Plekha3 KO Female
F
12wk
B6N(Cg)-Plekha3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Plekha3 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Plekha3 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Plekha3 WT Male (Mean ± SD) | Plekha3 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 56.75 ± 7.16 | 0.1007 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 37.48 ± 6.93 | 0.0190* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 17.87 ± 3.08 | 0.0382* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 1.21 ± 0.61 | <0.001* |
| Body Weight (g) | 27.49 ± 2.14 | 26.05 ± 0.90 | 0.1243 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.440 ± 0.049 | 0.0566 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 19.11 ± 2.56 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 66.96 ± 7.35 | 0.0091* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.24 ± 0.10 | 0.7791 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 33.94 ± 5.24 | 0.0328* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 33.04 ± 7.35 | 0.0091* |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 3.23 ± 0.36 | 0.0188* |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 256.75 ± 32.56 | 0.0049* |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 58.71 ± 5.88 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 2.24 ± 0.78 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 1.92 ± 0.74 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 0.89 ± 0.43 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 83.47 ± 5.38 | 0.1807 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 67.60 ± 6.00 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 37.55 ± 12.19 | 0.0238* |