Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Elk1 KO Male
M
12wk
B6N(Cg)-Elk1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Elk1 KO Female
F
12wk
B6N(Cg)-Elk1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Elk1 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Elk1 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Elk1 WT Male (Mean ± SD) | Elk1 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 71.45 ± 2.16 | 45.07 ± 18.15 | 0.0062* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 37.75 ± 5.11 | 17.37 ± 8.25 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 35.07 ± 2.99 | 29.03 ± 10.22 | 0.1904 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.95 ± 0.97 | 0.82 ± 0.47 | <0.001* |
| Body Weight (g) | 25.32 ± 1.77 | 25.48 ± 1.11 | 0.8377 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.365 ± 0.081 | 0.193 ± 0.062 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 12.36 ± 1.77 | 18.26 ± 3.15 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 51.58 ± 5.21 | 36.19 ± 6.52 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.35 ± 0.15 | 1.16 ± 0.21 | 0.0798 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 26.00 ± 3.15 | 15.54 ± 4.13 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 48.43 ± 5.21 | 63.81 ± 6.52 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.44 ± 0.26 | 3.35 ± 0.50 | 0.0010* |
| Trabecular Spacing (Tb.Sp) (µm) | 366.60 ± 43.71 | 252.30 ± 53.03 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 49.05 ± 4.62 | 53.88 ± 6.53 | 0.1323 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 18.73 ± 2.70 | 5.90 ± 1.80 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.35 ± 1.39 | 1.62 ± 0.54 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 11.41 ± 3.07 | 4.40 ± 1.67 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 82.47 ± 2.81 | 76.31 ± 11.51 | 0.2072 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 40.19 ± 7.62 | 27.75 ± 5.95 | 0.0064* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 59.81 ± 7.62 | 72.25 ± 5.95 | 0.0064* |