Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Osm KO Male
M
12wk
B6N(Cg)-Osm<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Osm KO Female
F
12wk
B6N(Cg)-Osm<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Osm WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Osm WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Osm WT Male (Mean ± SD) | Osm KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 47.79 ± 8.66 | 51.33 ± 6.67 | 0.4278 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 22.21 ± 3.50 | 26.74 ± 3.92 | 0.0675 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 28.11 ± 3.57 | 24.45 ± 4.08 | 0.1409 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 0.65 ± 0.16 | 3.63 ± 1.02 | 0.0011* |
| Body Weight (g) | 23.65 ± 2.19 | 19.70 ± 2.06 | 0.0037* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.290 ± 0.050 | 0.281 ± 0.038 | 0.7403 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 11.44 ± 3.33 | 12.04 ± 3.78 | 0.7578 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 43.95 ± 4.13 | 52.42 ± 3.09 | 0.0030* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.503 ± 0.092 | 1.163 ± 0.092 | <0.001* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 18.74 ± 2.66 | 24.60 ± 1.72 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 56.05 ± 4.13 | 47.58 ± 3.09 | 0.0030* |
| Trabecular Number (Tb.N) (#/mm) | 2.35 ± 0.44 | 2.35 ± 0.64 | 0.9908 |
| Trabecular Spacing (Tb.Sp) (µm) | 398.58 ± 82.43 | 413.09 ± 131.27 | 0.8080 |
| Trabecular Thickness (Tb.Th) (µm) | 48.57 ± 5.52 | 51.47 ± 5.06 | 0.3222 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 6.72 ± 1.86 | 17.27 ± 1.40 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 1.81 ± 1.01 | 7.73 ± 1.35 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 4.33 ± 1.72 | 9.71 ± 1.04 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 75.72 ± 8.16 | 74.50 ± 10.53 | 0.8125 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 28.03 ± 9.82 | 44.34 ± 6.03 | 0.0061* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 71.97 ± 9.82 | 55.66 ± 6.03 | 0.0061* |