Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Spp1 KO Male
M
12wk
B6N(Cg)-Spp1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Spp1 KO Female
F
12wk
B6N(Cg)-Spp1<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Spp1 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Spp1 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Spp1 WT Male (Mean ± SD) | Spp1 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 50.60 ± 5.88 | 35.43 ± 11.24 | 0.0069* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 29.00 ± 4.87 | 16.68 ± 5.81 | 0.0011* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 22.01 ± 3.66 | 17.01 ± 4.76 | 0.0524 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.46 ± 0.48 | 0.76 ± 0.53 | <0.001* |
| Body Weight (g) | 27.49 ± 2.14 | 26.18 ± 1.66 | 0.2210 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.366 ± 0.074 | 0.284 ± 0.037 | 0.0286* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.61 ± 1.37 | 13.11 ± 1.80 | 0.5658 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.60 ± 5.31 | 48.11 ± 3.35 | 0.0048* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.26 ± 0.16 | 1.37 ± 0.13 | 0.1786 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 28.20 ± 3.69 | 20.21 ± 1.66 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.40 ± 5.31 | 51.89 ± 3.35 | 0.0048* |
| Trabecular Number (Tb.N) (#/mm) | 2.80 ± 0.24 | 2.51 ± 0.32 | 0.0773 |
| Trabecular Spacing (Tb.Sp) (µm) | 313.32 ± 30.86 | 354.63 ± 50.37 | 0.0855 |
| Trabecular Thickness (Tb.Th) (µm) | 47.04 ± 2.35 | 52.03 ± 5.69 | 0.0595 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 15.93 ± 1.89 | 16.23 ± 4.74 | 0.8772 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.66 ± 0.89 | 4.59 ± 1.92 | 0.0023* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.00 ± 1.80 | 11.10 ± 4.51 | 0.1193 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 86.91 ± 3.57 | 82.09 ± 7.23 | 0.1358 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 49.00 ± 6.11 | 31.15 ± 3.14 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.00 ± 6.11 | 68.85 ± 3.14 | <0.001* |