Skeletal Phenotyping of Snx15 Knockout Mice

ROSSA-20260926-2E41

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Snx15 KO Male M 12wk
B6N(Cg)-Snx15<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Snx15 KO Female F 12wk
B6N(Cg)-Snx15<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Snx15 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Snx15 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Snx15 WT Male (Mean ± SD) Snx15 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 24.87 ± 2.15 24.98 ± 1.60 0.9191
Bone Mineral Density (mg/ccm HA) 1,150.63 ± 12.21 1,160.40 ± 6.44 0.0822
Cortical Area (mm^2) 0.760 ± 0.090 0.752 ± 0.038 0.8290
Cortical Area / Total Area (%) 40.37 ± 1.94 42.00 ± 1.37 0.0925
Cortical Mask (dimensionless) 0.762 ± 0.091 0.754 ± 0.038 0.8279
Cortical Porosity (%) 0.284 ± 0.040 0.276 ± 0.047 0.7199
Cortical Thickness (mm) 0.168 ± 0.011 0.1685 ± 0.0090 0.8564
Endocortical Perimeter (mm) 3.75 ± 0.31 3.608 ± 0.096 0.2705
Length (mm) 14.91 ± 0.33 14.66 ± 0.18 0.0999
Marrow Area (mm^2) 1.13 ± 0.19 1.036 ± 0.055 0.2514
Maximum Distance from Centroid (mm) 1.96 ± 0.17 1.933 ± 0.071 0.7417
Maximum Moment of Inertia (mm^4) 0.258 ± 0.070 0.247 ± 0.024 0.7046
Minimum Distance from Centroid (mm) 1.32 ± 0.10 1.249 ± 0.029 0.1248
Minimum Moment of Inertia (mm^4) 0.137 ± 0.037 0.1180 ± 0.0097 0.2410
Periosteal Perimeter (mm) 4.90 ± 0.54 4.60 ± 0.17 0.1906
Polar Moment of Inertia (mm^4) 0.39 ± 0.11 0.365 ± 0.033 0.4991
Pore Area (mm^2) 0.0022 ± 0.0004 0.0021 ± 0.0004 0.7042
Section Modulus about Maximum Moment of Inertia (mm^3) 0.259 ± 0.048 0.255 ± 0.017 0.8158
Section Modulus about Minimum Moment of Inertia (mm^3) 0.204 ± 0.040 0.189 ± 0.013 0.3515
Tissue Mineral Density (mg/ccm HA) 1,214.53 ± 10.99 1,224.78 ± 7.06 0.0568
Total Area (mm^2) 1.89 ± 0.27 1.790 ± 0.079 0.3690