Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Sptssb KO Male
M
12wk
B6N(Cg)-Sptssb<tm1b(KOMP)Mbp>/J (C57BL/6NTac)
• KO/KO
Sptssb KO Female
F
12wk
B6N(Cg)-Sptssb<tm1b(KOMP)Mbp>/J (C57BL/6NTac)
• KO/KO
Sptssb WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Sptssb WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Sptssb WT Male (Mean ± SD) | Sptssb KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 63.27 ± 14.77 | 73.27 ± 3.47 | 0.1032 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 34.78 ± 8.96 | 36.67 ± 3.25 | 0.6144 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 33.78 ± 4.14 | 37.36 ± 1.78 | 0.0590 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.67 ± 1.30 | 2.87 ± 0.90 | 0.2369 |
| Body Weight (g) | 25.98 ± 2.26 | 25.82 ± 0.90 | 0.8687 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.354 ± 0.089 | 0.338 ± 0.036 | 0.6593 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 13.18 ± 2.92 | 14.84 ± 2.43 | 0.2664 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 49.80 ± 6.95 | 49.40 ± 2.89 | 0.8937 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.33 ± 0.13 | 1.388 ± 0.065 | 0.3089 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 24.62 ± 4.46 | 24.37 ± 2.11 | 0.8942 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 50.20 ± 6.95 | 50.60 ± 2.89 | 0.8937 |
| Trabecular Number (Tb.N) (#/mm) | 2.61 ± 0.49 | 2.90 ± 0.40 | 0.2498 |
| Trabecular Spacing (Tb.Sp) (µm) | 348.22 ± 66.42 | 302.53 ± 50.78 | 0.1702 |
| Trabecular Thickness (Tb.Th) (µm) | 49.01 ± 4.51 | 52.43 ± 3.68 | 0.1435 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 17.05 ± 5.33 | 12.15 ± 2.79 | 0.0488* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 6.37 ± 2.72 | 4.60 ± 1.32 | 0.1669 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 10.28 ± 3.86 | 7.41 ± 2.08 | 0.1249 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 81.53 ± 3.78 | 86.28 ± 2.23 | 0.0125* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 37.45 ± 9.71 | 38.42 ± 2.10 | 0.8045 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 62.55 ± 9.71 | 61.58 ± 2.10 | 0.8045 |