Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Ccdc120 KO Male
M
12wk
B6N(Cg)-Ccdc120 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Ccdc120 KO Female
F
12wk
B6N(Cg)-Ccdc120 tm1.1(KOMP)Vlcg/J (C57BL/6NTac)
• KO/KO
Ccdc120 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Ccdc120 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Ccdc120 WT Male (Mean ± SD) | Ccdc120 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 62.47 ± 10.34 | 63.63 ± 4.12 | 0.7899 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 34.91 ± 6.56 | 29.52 ± 4.05 | 0.0941 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 27.28 ± 4.11 | 33.64 ± 4.41 | 0.0190* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 6.41 ± 1.47 | 5.11 ± 1.86 | 0.2288 |
| Body Weight (g) | 28.75 ± 3.22 | 27.95 ± 1.65 | 0.5704 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.359 ± 0.053 | 0.345 ± 0.080 | 0.7002 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 14.29 ± 1.60 | 15.41 ± 3.35 | 0.4447 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 55.93 ± 2.99 | 46.82 ± 4.99 | 0.0017* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.18 ± 0.18 | 1.41 ± 0.13 | 0.0149* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 29.88 ± 1.94 | 23.79 ± 2.34 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 44.07 ± 2.99 | 53.18 ± 4.99 | 0.0017* |
| Trabecular Number (Tb.N) (#/mm) | 4.69 ± 0.53 | 4.71 ± 1.03 | 0.9587 |
| Trabecular Spacing (Tb.Sp) (µm) | 187.57 ± 19.83 | 196.07 ± 63.47 | 0.7433 |
| Trabecular Thickness (Tb.Th) (µm) | 30.98 ± 5.01 | 31.91 ± 3.89 | 0.7065 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 28.20 ± 6.77 | 27.83 ± 2.49 | 0.8930 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 12.54 ± 2.67 | 11.41 ± 2.58 | 0.4521 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 15.81 ± 4.66 | 17.28 ± 2.26 | 0.4731 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 78.76 ± 3.72 | 78.08 ± 4.17 | 0.7513 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 44.96 ± 3.56 | 39.42 ± 4.83 | 0.0367* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 55.04 ± 3.56 | 60.58 ± 4.83 | 0.0367* |