Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Neurl2 KO Male
M
12wk
B6N(Cg)-Neurl2<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Neurl2 KO Female
F
12wk
B6N(Cg)-Neurl2<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Neurl2 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Neurl2 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Neurl2 WT Male (Mean ± SD) | Neurl2 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 71.45 ± 2.16 | 69.10 ± 9.07 | 0.5251 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 37.75 ± 5.11 | 28.92 ± 8.14 | 0.0514 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 35.07 ± 2.99 | 38.80 ± 7.64 | 0.2963 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 3.95 ± 0.97 | 2.20 ± 0.35 | 0.0027* |
| Body Weight (g) | 25.32 ± 1.77 | 26.05 ± 1.56 | 0.4258 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.365 ± 0.081 | 0.31 ± 0.11 | 0.3037 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 12.36 ± 1.77 | 17.33 ± 1.21 | <0.001* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 51.58 ± 5.21 | 42.67 ± 9.29 | 0.0713 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.35 ± 0.15 | 1.36 ± 0.22 | 0.8726 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 26.00 ± 3.15 | 20.48 ± 6.09 | 0.0646 |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 48.43 ± 5.21 | 57.33 ± 9.29 | 0.0713 |
| Trabecular Number (Tb.N) (#/mm) | 2.44 ± 0.26 | 2.64 ± 0.18 | 0.1021 |
| Trabecular Spacing (Tb.Sp) (µm) | 366.60 ± 43.71 | 319.40 ± 28.95 | 0.0320* |
| Trabecular Thickness (Tb.Th) (µm) | 49.05 ± 4.62 | 60.90 ± 3.55 | <0.001* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 18.73 ± 2.70 | 9.03 ± 1.06 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 7.35 ± 1.39 | 3.55 ± 0.88 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 11.41 ± 3.07 | 6.37 ± 1.17 | 0.0029* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 82.47 ± 2.81 | 86.74 ± 7.41 | 0.1760 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 40.19 ± 7.62 | 35.67 ± 8.13 | 0.3429 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 59.81 ± 7.62 | 64.33 ± 8.13 | 0.3429 |