Skeletal Phenotyping of Nfatc4 Knockout Mice

ROSSA-20260926-2067

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Nfatc4 KO Male M 12wk
B6N(Cg)-Nfatc4<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Nfatc4 KO Female F 12wk
B6N(Cg)-Nfatc4<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Nfatc4 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Nfatc4 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Nfatc4 WT Male (Mean ± SD) Nfatc4 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 24.83 ± 3.50 23.05 ± 1.62 0.2718
Bone Mineral Density (mg/ccm HA) 1,143.37 ± 7.98 1,132.10 ± 8.35 0.0273*
Cortical Area (mm^2) 0.646 ± 0.037 0.695 ± 0.084 0.1923
Cortical Area / Total Area (%) 41.03 ± 2.71 38.64 ± 1.45 0.0738
Cortical Mask (dimensionless) 0.648 ± 0.037 0.697 ± 0.084 0.1931
Cortical Porosity (%) 0.252 ± 0.023 0.236 ± 0.029 0.2888
Cortical Thickness (mm) 0.1559 ± 0.0050 0.153 ± 0.011 0.5272
Endocortical Perimeter (mm) 3.42 ± 0.26 3.72 ± 0.24 0.0586
Length (mm) 14.56 ± 0.27 14.64 ± 0.24 0.5829
Marrow Area (mm^2) 0.94 ± 0.14 1.10 ± 0.15 0.0609
Maximum Distance from Centroid (mm) 1.80 ± 0.14 1.96 ± 0.11 0.0424*
Maximum Moment of Inertia (mm^4) 0.188 ± 0.038 0.235 ± 0.056 0.0955
Minimum Distance from Centroid (mm) 1.192 ± 0.035 1.248 ± 0.090 0.1559
Minimum Moment of Inertia (mm^4) 0.093 ± 0.015 0.115 ± 0.031 0.1278
Periosteal Perimeter (mm) 4.31 ± 0.43 4.70 ± 0.43 0.1229
Polar Moment of Inertia (mm^4) 0.281 ± 0.053 0.350 ± 0.087 0.1029
Pore Area (mm^2) 0.0016 ± 0.0002 0.0016 ± 0.0002 0.9771
Section Modulus about Maximum Moment of Inertia (mm^3) 0.206 ± 0.028 0.238 ± 0.043 0.1372
Section Modulus about Minimum Moment of Inertia (mm^3) 0.156 ± 0.021 0.182 ± 0.035 0.1258
Tissue Mineral Density (mg/ccm HA) 1,208.83 ± 9.14 1,195.73 ± 7.72 0.0159*
Total Area (mm^2) 1.59 ± 0.18 1.80 ± 0.23 0.0773