Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Arrb1 KO Male
M
12wk
B6N(Cg)-Arrb1<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Arrb1 KO Female
F
12wk
B6N(Cg)-Arrb1<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Arrb1 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Arrb1 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Arrb1 WT Male (Mean ± SD) | Arrb1 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 76.20 ± 3.75 | 71.18 ± 5.23 | 0.0579 |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 43.65 ± 2.59 | 35.67 ± 7.45 | 0.0267* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 33.24 ± 1.57 | 34.99 ± 3.01 | 0.2206 |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.62 ± 0.82 | 3.47 ± 0.64 | 0.0143* |
| Body Weight (g) | 20.33 ± 0.89 | 19.54 ± 0.86 | 0.1127 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.477 ± 0.073 | 0.39 ± 0.13 | 0.1680 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.63 ± 0.81 | 7.36 ± 2.37 | 0.0040* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.73 ± 1.96 | 49.99 ± 7.30 | 0.0464* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.55 ± 0.14 | 1.53 ± 0.22 | 0.8524 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 31.63 ± 2.25 | 25.31 ± 6.03 | 0.0296* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.27 ± 1.96 | 50.01 ± 7.30 | 0.0464* |
| Trabecular Number (Tb.N) (#/mm) | 2.11 ± 0.15 | 1.81 ± 0.41 | 0.0835 |
| Trabecular Spacing (Tb.Sp) (µm) | 428.83 ± 32.50 | 560.92 ± 167.12 | 0.0593 |
| Trabecular Thickness (Tb.Th) (µm) | 49.82 ± 2.79 | 40.64 ± 5.65 | 0.0018* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 16.43 ± 3.82 | 14.74 ± 1.42 | 0.3011 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.21 ± 1.91 | 5.91 ± 1.40 | 0.0270* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.77 ± 2.47 | 9.04 ± 2.15 | 0.8371 |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 85.28 ± 2.97 | 73.52 ± 10.95 | 0.0253* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 48.86 ± 4.36 | 40.18 ± 10.82 | 0.0817 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.14 ± 4.36 | 59.82 ± 10.82 | 0.0817 |