Skeletal Phenotyping of Rnf112 Knockout Mice

ROSSA-20260926-1E9C

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Rnf112 KO Male M 12wk
B6N(Cg)-Rnf112<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Rnf112 KO Female F 12wk
B6N(Cg)-Rnf112<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Rnf112 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Rnf112 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Rnf112 WT Male (Mean ± SD) Rnf112 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 27.49 ± 2.14 25.90 ± 1.46 0.1276
Bone Mineral Density (mg/ccm HA) 1,134.99 ± 7.75 1,156.51 ± 7.42 <0.001*
Cortical Area (mm^2) 0.680 ± 0.063 0.750 ± 0.071 0.0713
Cortical Area / Total Area (%) 38.84 ± 1.31 42.41 ± 1.74 <0.001*
Cortical Mask (dimensionless) 0.682 ± 0.063 0.752 ± 0.071 0.0704
Cortical Porosity (%) 0.248 ± 0.024 0.272 ± 0.058 0.3409
Cortical Thickness (mm) 0.155 ± 0.011 0.170 ± 0.015 0.0572
Endocortical Perimeter (mm) 3.66 ± 0.16 3.566 ± 0.053 0.1637
Length (mm) 14.74 ± 0.21 14.78 ± 0.24 0.7326
Marrow Area (mm^2) 1.069 ± 0.093 1.012 ± 0.030 0.1577
Maximum Distance from Centroid (mm) 1.911 ± 0.089 1.963 ± 0.065 0.2386
Maximum Moment of Inertia (mm^4) 0.223 ± 0.039 0.251 ± 0.036 0.1933
Minimum Distance from Centroid (mm) 1.237 ± 0.050 1.211 ± 0.046 0.3245
Minimum Moment of Inertia (mm^4) 0.109 ± 0.019 0.112 ± 0.015 0.6943
Periosteal Perimeter (mm) 4.64 ± 0.31 4.62 ± 0.22 0.8680
Polar Moment of Inertia (mm^4) 0.332 ± 0.057 0.363 ± 0.050 0.2957
Pore Area (mm^2) 0.0017 ± 0.0002 0.0020 ± 0.0004 0.0884
Section Modulus about Maximum Moment of Inertia (mm^3) 0.232 ± 0.031 0.255 ± 0.029 0.1812
Section Modulus about Minimum Moment of Inertia (mm^3) 0.175 ± 0.024 0.185 ± 0.017 0.3830
Tissue Mineral Density (mg/ccm HA) 1,198.45 ± 8.55 1,218.85 ± 9.20 <0.001*
Total Area (mm^2) 1.75 ± 0.15 1.764 ± 0.098 0.8495