Skeletal Phenotyping of Hsf2 Knockout Mice

ROSSA-20260926-17D0

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Hsf2 KO Male M 12wk
B6N(Cg)-Hsf2<tm1b(KOMP)Wtsi>/3J (C57BL/6NTac) • KO/KO
Hsf2 KO Female F 12wk
B6N(Cg)-Hsf2<tm1b(KOMP)Wtsi>/3J (C57BL/6NTac) • KO/KO
Hsf2 WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Hsf2 WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Hsf2 WT Male (Mean ± SD) Hsf2 KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 24.87 ± 2.15 23.24 ± 1.02 0.1123
Bone Mineral Density (mg/ccm HA) 1,150.63 ± 12.21 1,151.74 ± 10.65 0.8594
Cortical Area (mm^2) 0.760 ± 0.090 0.691 ± 0.049 0.0982
Cortical Area / Total Area (%) 40.37 ± 1.94 40.14 ± 1.22 0.7939
Cortical Mask (dimensionless) 0.762 ± 0.091 0.693 ± 0.049 0.0965
Cortical Porosity (%) 0.284 ± 0.040 0.228 ± 0.023 0.0061*
Cortical Thickness (mm) 0.168 ± 0.011 0.1581 ± 0.0088 0.1059
Endocortical Perimeter (mm) 3.75 ± 0.31 3.592 ± 0.093 0.2264
Length (mm) 14.91 ± 0.33 14.77 ± 0.28 0.4060
Marrow Area (mm^2) 1.13 ± 0.19 1.028 ± 0.053 0.2120
Maximum Distance from Centroid (mm) 1.96 ± 0.17 1.882 ± 0.092 0.3330
Maximum Moment of Inertia (mm^4) 0.258 ± 0.070 0.214 ± 0.026 0.1477
Minimum Distance from Centroid (mm) 1.32 ± 0.10 1.257 ± 0.038 0.1779
Minimum Moment of Inertia (mm^4) 0.137 ± 0.037 0.109 ± 0.013 0.0923
Periosteal Perimeter (mm) 4.90 ± 0.54 4.53 ± 0.23 0.1216
Polar Moment of Inertia (mm^4) 0.39 ± 0.11 0.323 ± 0.038 0.1226
Pore Area (mm^2) 0.0022 ± 0.0004 0.0016 ± 0.0002 0.0044*
Section Modulus about Maximum Moment of Inertia (mm^3) 0.259 ± 0.048 0.227 ± 0.020 0.1225
Section Modulus about Minimum Moment of Inertia (mm^3) 0.204 ± 0.040 0.174 ± 0.016 0.0825
Tissue Mineral Density (mg/ccm HA) 1,214.53 ± 10.99 1,219.46 ± 9.71 0.3886
Total Area (mm^2) 1.89 ± 0.27 1.720 ± 0.094 0.1426