Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Rin3 KO Male
M
12wk
B6N(Cg)-Rin3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Rin3 KO Female
F
12wk
B6N(Cg)-Rin3<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Rin3 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Rin3 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Rin3 WT Male (Mean ± SD) | Rin3 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 63.09 ± 8.31 | 73.94 ± 4.24 | 0.0124* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 36.41 ± 5.96 | 36.93 ± 2.76 | 0.8620 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 27.47 ± 3.28 | 37.34 ± 3.33 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 5.99 ± 1.39 | 2.27 ± 0.63 | <0.001* |
| Body Weight (g) | 24.25 ± 1.08 | 26.80 ± 2.29 | 0.0208* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.447 ± 0.066 | 0.289 ± 0.030 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.02 ± 1.74 | 13.73 ± 2.40 | 0.0098* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.80 ± 3.21 | 49.78 ± 2.83 | 0.0043* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.457 ± 0.065 | 1.17 ± 0.12 | <0.001* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 29.86 ± 3.40 | 24.90 ± 1.99 | 0.0095* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.20 ± 3.21 | 50.22 ± 2.83 | 0.0043* |
| Trabecular Number (Tb.N) (#/mm) | 2.32 ± 0.30 | 2.71 ± 0.21 | 0.0199* |
| Trabecular Spacing (Tb.Sp) (µm) | 396.65 ± 65.14 | 323.94 ± 30.01 | 0.0288* |
| Trabecular Thickness (Tb.Th) (µm) | 45.71 ± 4.15 | 50.21 ± 6.86 | 0.1708 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 26.56 ± 5.06 | 8.55 ± 1.94 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 11.97 ± 2.03 | 4.01 ± 0.91 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 14.29 ± 3.85 | 4.17 ± 1.08 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.82 ± 4.86 | 92.25 ± 2.41 | <0.001* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 46.12 ± 4.92 | 49.28 ± 2.53 | 0.2341 |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 53.88 ± 4.92 | 50.72 ± 2.53 | 0.2341 |