Skeletal Phenotyping of Syce1l Knockout Mice

ROSSA-20260926-0C4E

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
Syce1l KO Male M 12wk
B6N(Cg)-Syce11<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Syce1l KO Female F 12wk
B6N(Cg)-Syce11<tm1.1(KOMP)Vlcg>/J (C57BL/6NTac) • KO/KO
Syce1l WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
Syce1l WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable Syce1l WT Male (Mean ± SD) Syce1l KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 28.21 ± 2.11 24.70 ± 1.21 0.0032*
Bone Mineral Density (mg/ccm HA) 1,135.37 ± 9.56 1,144.28 ± 7.30 0.0703
Cortical Area (mm^2) 0.685 ± 0.059 0.708 ± 0.042 0.4308
Cortical Area / Total Area (%) 38.71 ± 1.21 40.92 ± 1.58 0.0106*
Cortical Mask (dimensionless) 0.687 ± 0.059 0.709 ± 0.043 0.4338
Cortical Porosity (%) 0.249 ± 0.026 0.231 ± 0.070 0.5255
Cortical Thickness (mm) 0.154 ± 0.011 0.161 ± 0.011 0.2339
Endocortical Perimeter (mm) 3.69 ± 0.14 3.578 ± 0.074 0.0874
Length (mm) 14.74 ± 0.22 14.52 ± 0.11 0.0400*
Marrow Area (mm^2) 1.083 ± 0.081 1.019 ± 0.042 0.0858
Maximum Distance from Centroid (mm) 1.912 ± 0.090 1.913 ± 0.041 0.9895
Maximum Moment of Inertia (mm^4) 0.225 ± 0.038 0.225 ± 0.018 0.9978
Minimum Distance from Centroid (mm) 1.244 ± 0.046 1.217 ± 0.030 0.2141
Minimum Moment of Inertia (mm^4) 0.112 ± 0.016 0.1084 ± 0.0099 0.6757
Periosteal Perimeter (mm) 4.67 ± 0.29 4.49 ± 0.12 0.1735
Polar Moment of Inertia (mm^4) 0.337 ± 0.054 0.334 ± 0.027 0.8931
Pore Area (mm^2) 0.0017 ± 0.0002 0.0017 ± 0.0006 0.8159
Section Modulus about Maximum Moment of Inertia (mm^3) 0.234 ± 0.029 0.236 ± 0.017 0.9360
Section Modulus about Minimum Moment of Inertia (mm^3) 0.179 ± 0.020 0.178 ± 0.013 0.9382
Tissue Mineral Density (mg/ccm HA) 1,198.35 ± 9.97 1,205.78 ± 7.92 0.1449
Total Area (mm^2) 1.77 ± 0.13 1.728 ± 0.065 0.4704