Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Rab36 KO Male
M
12wk
B6N(Cg)-Rab36<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Rab36 KO Female
F
12wk
B6N(Cg)-Rab36<tm1b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Rab36 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Rab36 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Rab36 WT Male (Mean ± SD) | Rab36 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 76.20 ± 3.75 | 63.65 ± 4.40 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 43.65 ± 2.59 | 34.21 ± 3.83 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 33.24 ± 1.57 | 29.78 ± 2.35 | 0.0193* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.62 ± 0.82 | 3.74 ± 0.34 | 0.0676 |
| Body Weight (g) | 20.33 ± 0.89 | 21.04 ± 1.00 | 0.2020 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.477 ± 0.073 | 0.404 ± 0.066 | 0.1361 |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.63 ± 0.81 | 8.78 ± 1.79 | 0.0299* |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 56.73 ± 1.96 | 53.34 ± 2.93 | 0.0535 |
| Mineral Apposition Rate (MAR) (µm/day) | 1.55 ± 0.14 | 1.43 ± 0.20 | 0.2599 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 31.63 ± 2.25 | 27.56 ± 1.70 | 0.0110* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 43.27 ± 1.96 | 46.66 ± 2.93 | 0.0535 |
| Trabecular Number (Tb.N) (#/mm) | 2.11 ± 0.15 | 1.88 ± 0.22 | 0.0435* |
| Trabecular Spacing (Tb.Sp) (µm) | 428.83 ± 32.50 | 499.60 ± 75.75 | 0.0435* |
| Trabecular Thickness (Tb.Th) (µm) | 49.82 ± 2.79 | 46.39 ± 5.21 | 0.1557 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 16.43 ± 3.82 | 19.84 ± 2.03 | 0.0708 |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.21 ± 1.91 | 8.73 ± 1.15 | 0.6316 |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 8.77 ± 2.47 | 11.71 ± 1.18 | 0.0473* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 85.28 ± 2.97 | 78.42 ± 6.73 | 0.0306* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 48.86 ± 4.36 | 42.61 ± 3.62 | 0.0374* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 51.14 ± 4.36 | 57.39 ± 3.62 | 0.0374* |