Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Moxd1 KO Male
M
12wk
B6N(Cg)-Moxd1<tm2b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Moxd1 KO Female
F
12wk
B6N(Cg)-Moxd1<tm2b(KOMP)Wtsi>/J (C57BL/6NTac)
• KO/KO
Moxd1 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Moxd1 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Moxd1 WT Male (Mean ± SD) | Moxd1 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 72.05 ± 3.56 | 59.77 ± 8.58 | 0.0064* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 37.10 ± 3.65 | 43.60 ± 7.17 | 0.0796 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 35.10 ± 3.12 | 16.51 ± 2.14 | <0.001* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 4.29 ± 1.09 | 1.92 ± 0.47 | <0.001* |
| Body Weight (g) | 24.71 ± 2.01 | 22.77 ± 1.16 | 0.0438* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.384 ± 0.082 | 0.551 ± 0.068 | 0.0023* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.99 ± 3.00 | 10.66 ± 1.40 | 0.7986 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 51.37 ± 3.73 | 72.36 ± 3.01 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.44 ± 0.14 | 1.30 ± 0.13 | 0.0720 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 26.81 ± 2.94 | 41.47 ± 2.72 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 48.63 ± 3.73 | 27.64 ± 3.01 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.25 ± 0.45 | 2.23 ± 0.27 | 0.9049 |
| Trabecular Spacing (Tb.Sp) (µm) | 417.34 ± 97.95 | 409.90 ± 62.95 | 0.8682 |
| Trabecular Thickness (Tb.Th) (µm) | 49.07 ± 6.44 | 50.08 ± 2.72 | 0.7066 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 21.10 ± 2.24 | 4.60 ± 1.34 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 8.70 ± 1.54 | 3.23 ± 0.89 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 12.84 ± 1.33 | 1.57 ± 0.55 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 77.65 ± 6.14 | 77.08 ± 6.34 | 0.8675 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 40.35 ± 5.49 | 68.90 ± 5.23 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 59.65 ± 5.49 | 31.10 ± 5.23 | <0.001* |