Skeletal Phenotyping of C1qa Knockout Mice

ROSSA-20260926-06E5

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Study Datasets
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Cortical
Microcomputed Tomography (µCT) 1 uploads
Bone: Femur Region: Trabecular
Microcomputed Tomography (µCT) 1 uploads
Bone: Vertebra Region: Trabecular
Sample Groups
C1qa KO Male M 12wk
B6N(Cg)-C1qa<tm1b(EUCOMM)Wtsi>/J (C57BL/6NTac) • KO/KO
C1qa KO Female F 12wk
B6N(Cg)-C1qa<tm1b(EUCOMM)Wtsi>/J (C57BL/6NTac) • KO/KO
C1qa WT Male Control M 12wk
C57BL/6NTac (C57BL/6NTac) • +/+
C1qa WT Female Control F 12wk
C57BL/6NTac (C57BL/6NTac) • +/+

Analysis Type: Microcomputed Tomography (µCT) Bone: Femur Region: Cortical

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Variable C1qa WT Male (Mean ± SD) C1qa KO Male (Mean ± SD) T-test (p-Value)
Body Weight (g) 24.87 ± 2.15 23.37 ± 1.74 0.1730
Bone Mineral Density (mg/ccm HA) 1,150.63 ± 12.21 1,166.07 ± 9.53 0.0196*
Cortical Area (mm^2) 0.760 ± 0.090 0.758 ± 0.090 0.9748
Cortical Area / Total Area (%) 40.37 ± 1.94 42.21 ± 1.53 0.0701
Cortical Mask (dimensionless) 0.762 ± 0.091 0.760 ± 0.090 0.9714
Cortical Porosity (%) 0.284 ± 0.040 0.258 ± 0.025 0.1616
Cortical Thickness (mm) 0.168 ± 0.011 0.173 ± 0.013 0.4621
Endocortical Perimeter (mm) 3.75 ± 0.31 3.60 ± 0.19 0.2872
Length (mm) 14.91 ± 0.33 14.83 ± 0.27 0.6372
Marrow Area (mm^2) 1.13 ± 0.19 1.03 ± 0.11 0.2750
Maximum Distance from Centroid (mm) 1.96 ± 0.17 1.93 ± 0.10 0.7566
Maximum Moment of Inertia (mm^4) 0.258 ± 0.070 0.246 ± 0.051 0.7379
Minimum Distance from Centroid (mm) 1.32 ± 0.10 1.259 ± 0.076 0.2410
Minimum Moment of Inertia (mm^4) 0.137 ± 0.037 0.123 ± 0.028 0.4574
Periosteal Perimeter (mm) 4.90 ± 0.54 4.65 ± 0.34 0.3210
Polar Moment of Inertia (mm^4) 0.39 ± 0.11 0.369 ± 0.079 0.6301
Pore Area (mm^2) 0.0022 ± 0.0004 0.0020 ± 0.0003 0.2685
Section Modulus about Maximum Moment of Inertia (mm^3) 0.259 ± 0.048 0.253 ± 0.039 0.7878
Section Modulus about Minimum Moment of Inertia (mm^3) 0.204 ± 0.040 0.194 ± 0.033 0.5938
Tissue Mineral Density (mg/ccm HA) 1,214.53 ± 10.99 1,231.00 ± 8.37 0.0070*
Total Area (mm^2) 1.89 ± 0.27 1.79 ± 0.19 0.4636