Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Cp KO Male
M
12wk
B6N(Cg)-Cp tm1b(KOMP)Wtsi/J (C57BL/6NTac)
• KO/KO
Cp KO Female
F
12wk
B6N(Cg)-Cp tm1b(KOMP)Wtsi/J (C57BL/6NTac)
• KO/KO
Cp WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Cp WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Cp WT Male (Mean ± SD) | Cp KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 44.46 ± 11.02 | 75.45 ± 5.50 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 18.07 ± 6.10 | 34.90 ± 2.55 | <0.001* |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 26.89 ± 6.21 | 40.45 ± 6.43 | 0.0045* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 1.00 ± 0.70 | 3.87 ± 0.89 | <0.001* |
| Body Weight (g) | 25.69 ± 2.19 | 20.5200 ± 0.0000 | <0.001* |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.282 ± 0.046 | 0.51 ± 0.10 | 0.0026* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 12.31 ± 2.31 | 11.27 ± 1.80 | 0.3638 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 39.78 ± 4.86 | 46.56 ± 4.94 | 0.0428* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.61 ± 0.19 | 2.00 ± 0.28 | 0.0147* |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 17.34 ± 1.83 | 25.31 ± 2.07 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 60.22 ± 4.86 | 53.44 ± 4.94 | 0.0428* |
| Trabecular Number (Tb.N) (#/mm) | 2.56 ± 0.33 | 3.88 ± 0.66 | <0.001* |
| Trabecular Spacing (Tb.Sp) (µm) | 354.28 ± 55.48 | 236.28 ± 41.57 | <0.001* |
| Trabecular Thickness (Tb.Th) (µm) | 46.39 ± 5.15 | 30.51 ± 10.20 | 0.0025* |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 12.98 ± 2.15 | 24.56 ± 2.47 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 3.48 ± 1.02 | 8.00 ± 1.06 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 9.83 ± 1.70 | 15.89 ± 2.39 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 76.32 ± 5.39 | 79.02 ± 3.90 | 0.3010 |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 25.72 ± 5.07 | 33.82 ± 4.34 | 0.0166* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 74.28 ± 5.07 | 66.18 ± 4.34 | 0.0166* |