Study Datasets
Bone Histomorphometry
1 uploads
Bone: Femur
Region: Trabecular
Bone Histomorphometry
1 uploads
Bone: Vertebra
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Cortical
Microcomputed Tomography (µCT)
1 uploads
Bone: Femur
Region: Trabecular
Microcomputed Tomography (µCT)
1 uploads
Bone: Vertebra
Region: Trabecular
Sample Groups
Dnajc28 KO Male
M
12wk
B6N(Cg)-Dnajc28 <tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Dnajc28 KO Female
F
12wk
B6N(Cg)-Dnajc28 <tm1.1(KOMP)Vlcg>/J (C57BL/6NTac)
• KO/KO
Dnajc28 WT Male
Control
M
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Dnajc28 WT Female
Control
F
12wk
C57BL/6NTac (C57BL/6NTac)
• +/+
Analysis Type: Bone Histomorphometry Bone: Femur Region: Trabecular
| Variable | Dnajc28 WT Male (Mean ± SD) | Dnajc28 KO Male (Mean ± SD) | T-test (p-Value) |
|---|---|---|---|
| Alkaline Phosphatase+ Bone Surface/Bone Surface (AP/BS) (%) | 57.17 ± 6.50 | 44.14 ± 13.66 | 0.0492* |
| Alkaline Phosphatase+ Bone Surface/Labeled Bone Surface (AP/L.BS) (%) | 21.17 ± 2.38 | 23.73 ± 7.74 | 0.4612 |
| Alkaline Phosphatase+ Bone Surface/Non-Labeled Bone Surface (AP/NL.BS) (%) | 36.42 ± 5.86 | 20.71 ± 6.77 | 0.0017* |
| AP+ TRAP+ Labeled Bone Surface/Bone Surface (AP+TRAP+L.BS/BS) (%) | 1.47 ± 0.38 | 0.76 ± 0.34 | 0.0075* |
| Body Weight (g) | 27.39 ± 1.23 | 23.78 ± 5.40 | 0.1564 |
| Bone Formation Rate/Bone Surface (BFR/BS) (µm3/µm2/day) | 0.227 ± 0.024 | 0.327 ± 0.042 | <0.001* |
| Bone Volume/Tissue Volume (BV/TV) (%) | 10.91 ± 2.03 | 9.16 ± 2.59 | 0.1969 |
| Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (L.S+AP/T.AP) (%) | 36.93 ± 3.03 | 53.11 ± 5.21 | <0.001* |
| Mineral Apposition Rate (MAR) (µm/day) | 1.37 ± 0.10 | 1.39 ± 0.19 | 0.7796 |
| Mineralizing Surface/Bone Surface (MS/BS) (%) | 16.46 ± 1.50 | 23.64 ± 2.90 | <0.001* |
| Non-Labeled Alkaline Phosphatase+ Surface/Total AP+ Surface (NL.S+AP/T.AP) (%) | 63.07 ± 3.03 | 46.89 ± 5.21 | <0.001* |
| Trabecular Number (Tb.N) (#/mm) | 2.58 ± 0.23 | 2.03 ± 0.51 | 0.0246* |
| Trabecular Spacing (Tb.Sp) (µm) | 353.44 ± 37.74 | 489.04 ± 159.94 | 0.0496* |
| Trabecular Thickness (Tb.Th) (µm) | 42.27 ± 6.22 | 45.88 ± 2.99 | 0.2150 |
| TRAP+ Bone Surface/Bone Surface (TRAP/BS) (%) | 26.12 ± 2.21 | 5.54 ± 1.78 | <0.001* |
| TRAP+ Bone Surface/Labeled Bone Surface (TRAP/L.BS) (%) | 6.33 ± 1.11 | 2.15 ± 0.76 | <0.001* |
| TRAP+ Bone Surface/Non-Labeled Bone Surface (TRAP/NL.BS) (%) | 22.00 ± 3.51 | 3.48 ± 1.05 | <0.001* |
| TRAP+ Bone Surface/Total TRAP+ Surface (TRAP/TRAP) (%) | 68.17 ± 5.31 | 79.65 ± 9.46 | 0.0169* |
| TRAP+ Labeled Bone Surface/TRAP+ Bone Surface (TRAP+L.BS/TRAP.BS) (%) | 22.46 ± 2.99 | 37.55 ± 3.74 | <0.001* |
| TRAP+ Non-Labeled Bone Surface/TRAP+ Bone Surface (TRAP+QS.BS/TRAP.BS) (%) | 77.54 ± 2.99 | 62.45 ± 3.74 | <0.001* |